Browsing by Author "Malago, J."

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Caudal mediastinal abscessation in an adult East African black headed Ewe -A case report
(TANZANIA VETERINARY ASSOCIATION, 2017) Makungu, M.; Malago, J.
A 4-year-old East African black headed ewe was presented to Sokoine University of Agriculture Animal Hospital with a history of loss of body condition and respiratory distress. Clinical examination revealed poor body condition, severe leukopenia with neutrophilia and lymphopenia. Radiographic examination of the thorax revealed an elongated caudal mediastinal mass with soft tissue opacity dorsal to caudal vena cava and caudal to the carina. The ewe was humanely euthanised due to deteriorated body condition. At post-mortem examination the mass contained caseous creamy material with early laminated appearance surrounded by a whitish fibrous capsule suggestive of chronic abscessation of caudal mediastinal lymph node. Corynebacterium pseudotuberculosis was isolated on bacterial culture of pus sample. A diagnosis of an abscessed caudal mediastinal lymph node as a result of Corynebacterium pseudotuberculosis infection was made. Thoracic radiography should be considered in sheep with chronic progressive emaciation and respiratory distress. Further, in sheep with caudal mediastinal mass, caseous lymphadenitis should be considered as one of the differential diagnoses.
Evaluation of baobab seed cake based diets for growth performance and carcass quality of pig in central zone, Tanzania
(AJOL, 2021) Magonka, J. M.; Komwihangilo, D. M.; Malago, J.
This study was carried out in Central Tanzania and aimed at evaluating the effect of Baobab seed cake (BSC) on growth performance and carcass quality of pigs. Twenty-four (24) weaners of both sexes were involved in the study which lasted for 84 days. Four diets were formulated with BSC replacing sunflower seed cake at four levels of 0, 7, 14 and 21% and allotted to four dietary treatments T1, T2, T3 and T4 respectively, in a completely randomized design. Results showed that the four levels of replacement had no significant effect on body weight gains although T2 outperformed the others in terms of weight gain with 23.19kg whereby T1 (20.54kg) and T3 (20.21kg) had almost similar weights and T4 had the lowest weight gain (15.52kg). The cost of production, carcass weights, and dressing percentages varied significantly (P≤ 0.05) whereby costs of production (in Tshs) were 151,643.28, 162,965.52, 150,820.03 and 117,646.74 for T1, T2, T3 and T4 respectively. Carcass weight and dressing percentages were 23kg, 20.5kg, 18.50kg, 9.50kgs and 55.4, 53.9, 51.4 and 48.7% for T1, T2, T3 and T4 respectively. Histopathology analyses of the carcasses indicated that there were no any detrimental changes resulting from an inclusion of BSC in pig diets thus the pork was fit for human consumption.
Hypertrophic osteopathy secondary to oesophageal foreign body in a dog - a case report
(2007) Makungu, M.; Malago, J.; Muhairwa, A. P.; Mgasa, M. N.
Hypertrophic osteopathy is a pathological disease process that occurs secondary to intra thoracic lesions that are either pulmonary or non pulmonary in origin. A 6-year-old female German shepherd cross was presented with complaints of losing body condition, anorexia, lameness, and swollen limbs. Clinical examination revealed swelling of all four limbs which were hard and painless on palpation. Radiographic examination of the limbs and the thoracic cavity revealed, irregular periosteal new bone formation along the shafts of most of the long bones and an oval-shaped 6 cm diameter radio dense caudal mediastinal mass. At post-mortem examination, an oesophageal diverticulum was found, filled with foul smelling creamy exudates and a bone foreign body firmly adherent to the wall. Hypertrophic osteopathy secondary to oesophageal foreign body was diagnosed based on history, clinical examination, radiography, post-mortem picture and histopathology.
Time and Tissue Dependent Expression of Heat Shock Protein 27, 70 and 90 in Mice Following Hyperthermia
(International Journal of Sciences: Basic and Applied Research, 2018) Malago, J.
Heat shock response is rapidly induced to protect cells from irreversible injury by stabilizing cellular synthetic and metabolic activities. Particularly, the response differentially protects against stresses, infections and inflammations. While it could be time- and tissue-dependent, it is not established as to how it exhibits. This study explored the expression of heat shock protein (Hsp) 27, 70 and 90 in intestines, kidneys, livers and lungs of mice undergoing hyperthermia at 42°C for 1 hr and recovering for 1-72 hr. The expression of these Hsps was determined by immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections. There was an increase in the expression of Hsp27, 70 and 90 that peaked at 6-12 hr and differentially declined at 48-72 hr. The peak expression was reached earlier in the lung and dropped sharply in the intestine while sustained for a longer time in the liver and kidney. At 72 hr only Hsp90 exhibited moderate expression in the lung and kidney. It is concluded that optimal expression of Hsps is time- and tissue- dependent and has narrow margin of peak expression in some tissues. This knowledge might contribute to designing therapeutic agents for curbing stresses, infections and inflammations that can be suppressed by Hsps.