Browsing by Author "Setsuda, Aogu"

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    Brief review on atypical human trypanosomiasis of trypanosoma lewisi
    (2016) Mafie, Eliakunda; Rupa, Fatema Hashem; Setsuda, Aogu; Saito-Ito, Atsuko; Sato, Hiroshi
    Trypanosomes (Kinetoplastea: Trypanosomatida: Trypanosomatidae), particularly salivarian trypanosome species as well as stercorarian Trypanosoma cruzi, are important parasites of humans and other animals that cause often fatal diseases. Stercorarian T. lewisi is known as a rat-specific species of the subgenus Herpetosoma. Rodent trypanosomes cause latent infections, and T. lewisi infection beyond the genus border, e.g. infection in mice, is considered to be virtually impossible. Nevertheless, nine human cases of T. lewisi infection have been reported in recent decades, with an increased incidence (five cases) in the last two decades. In the present review, we summarize the records of atypical human trypanosomiasis ascribed to T. lewisi infection and provide information on the background of disease incidences and possible PCR-based diagnostic approaches.
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    Genetic diversity of cervid trypanosoma theileri In Honshu sika deer (cervus nippon) in Japan
    (Cambridge University Press, 2021) Rosyadi, Imron; Setsuda, Aogu; Eliakunda, Mafie; Takano, Ai; Maeda, Ken; Saito-Ito, Atsuko; Suzuki, Kazuo; Sato, Hiroshi
    The taxonomy of ruminant Trypanosoma theileri and its relatives (Kinetoplastida: Trypanosomatidae) is controversial, with recent phylogenetic studies segregating T. theileri in cattle and other ruminants worldwide into two major genetic lineages (the TthI and TthII clades) based on genetic markers. In the present study, T. theileri-like trypanosomes isolated from Honshu sika deer (Cervus nippon) in the western Japan (YMG isolate) were gen- etically characterized using a number of genetic markers. Sika deer trypanosomes of the YMG isolate were genetically different from the Trypanosoma sp. TSD1 isolate previously recorded from Hokkaido sika deer in northern Japan, with the former trypanosome isolate being gen- etically closer to European cervid trypanosomes and the bovine T. theileri TthII lineage. In contrast, the latter isolate exhibited greater relatedness to North American cervid trypano- somes and the bovine T. theileri TthI lineage, although a clear genetic distinction between these was apparent. Furthermore, trypanosomes in Honshu sika deer from the central part of Japan harboured additional genetic diversity and were closer to either TSD1 or YMG iso- lates, while distinct from known T. theileri-related genotypes. Importantly, cervids and wild ruminants worldwide might harbour divergent descendants of a T. theileri ancestor, which exhibit rigid host specificity to either bovines or cervid species.