Bacteriostatic and haemolytic activities of extracts and compounds of commiphora swynnertonii

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dc.contributor.authorMsengwa, Zaituni
dc.contributor.authorCredo, David
dc.contributor.authorMafuru, Magesa
dc.contributor.authorMwesongo, James
dc.contributor.authorMabiki, Faith Philemon
dc.contributor.authorMwang’onde, Beda John
dc.contributor.authorMtambo, Madundo Mkumbukwa
dc.contributor.authorKusiluka, Lughano Jeremy
dc.contributor.authorMdegela, Robinson Hammerthon
dc.contributor.authorOlsen, John Elmerdahl
dc.date.accessioned2023-08-02T09:44:44Z
dc.date.available2023-08-02T09:44:44Z
dc.date.issued2023
dc.descriptionJournal Articleen_US
dc.description.abstractBackground and objective: Commiphora swynnertonii (Pax) is used in traditional medicine to treat infectious diseases. Previous studies have reported antimicrobial activity of this plant; however, the activity of compounds that are present in extracts of this plant has not been thoroughly documented. Likewise, the primary mode of action (bactericidal or bacteriostatic) and the possible toxicity on red blood cells have not been reported. Methods: Extracts of leaves, whole root, root bark, root wood, whole stem, stem bark and stem wood, were produced using hexane, dichloromethane, methanol and water. Cold and hot extraction methods were employed. Antibacterial activity of extracts was tested against selected medically important Gram-positive and Gram-negative bacteria by growth inhibition, minimum inhibitory concentrations and time kill assays. Moreover, haemolytic activity against sheep red blood cells was determined in vitro. Results: The hexane extracts of whole root and root bark, methanol extracts of root wood, and dichloromethane extracts from the leaves of C. swynnertonii inhibited the growth of S. aureus. MIC values for the extracts and compounds, indicated moderate activity against Gram-positive bacteria (Staphylococcus aureus, Streptococci species and Enterococci species) while the activity against Gram-negative bacteria (Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, Salmonella species, Shigella sonnei and Yersinia enterocolitica) was weak. Time kill profiles showed the extracts have bacteriostatic activity against S. aureus, and low haemolytic effect, except for extracts of whole root and leaves at the concentration of 1000 μg/mL. Conclusion: Extracts of C. swynnertonii showed bacteriostatic activity against Gram-positive bacteria with low toxicity on red blood cells.en_US
dc.identifier.citationMsengwa Z, Credo D, Mafuru M, Mwesongo J, Mabiki FP, Mwang’onde BJ, Mtambo MM, Kusiluka LJ, Mdegela RH, Olsen JE. Bacteriostatic and haemolytic activities of extracts and compounds of Commiphora swynnertonii. Res J Pharmacogn. 2023; 10(2): 47–56.en_US
dc.identifier.urihttp://www.suaire.sua.ac.tz/handle/123456789/5510
dc.language.isoenen_US
dc.publisherResearch Journal of Pharmacognosyen_US
dc.subjectAntibacterialen_US
dc.subjectCommiphora swynnertoniien_US
dc.subjectMedicinal planten_US
dc.subjectRed blood cellsen_US
dc.titleBacteriostatic and haemolytic activities of extracts and compounds of commiphora swynnertoniien_US
dc.typeArticleen_US
dc.urlDOI: 10.22127/RJP.2023.370231.2009en_US

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