Effect of A. nilotica pods and A. lebbeck stem bark extracts on the reproductive system of male mastomys natalensis: an anti-fertility studies
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
African journal of biological sciences
Abstract
The contraceptive potential of Acacia nilotica pods and Albizzia lebbeck stem bark
methanolic extracts were evaluated in male rodent pests. Ninety (90)
multimammate rats (M. natalensis) were randomized into a 3 × 3 factorial design
for treatment groups (control, A. lebbeck and A. nilotica) (n = 10) and treatment
durations (15, 30, or 60 days). Control rats consumed plain feed. Treated rats
consumed feed with 2% w/w of either of the plant extract. Following treatment,
male rats were mated to untreated females before they were sedated in ether and
humanely sacrificed. Assessments were done on fertility success rates (number
of impregnated females), weight of testes and reproductive glands, sperm cell
parameters, and testes histopathology. Fertility success rate was reduced to 0%
in the A. nilotica treated rats at all the treatment durations and in the A. lebbeck
treated rats after 60 days of treatment. Also, the extract-treated rats revealed a
significant reduction in the testes, seminal vesicles, and epididymides weights
compared to the control group. Moreover, sperm cell density and the proportions
of live and progressively motile spermatozoa were significantly reduced and
there were numerous damaged seminiferous tubules reflected by sloughed off
germ cells, thinned germinal epithelium and widened empty lumen in the extract-
treated rats. Thus, treatment with A. nilotica or A. lebbeck extract in male M.
natalensis reduced their fertility success rates through distortion of testicular
structure and disruption of spermatogenesis.
Description
Journal Article
Keywords
Seminiferous tubule, Multimammate rat, Sperms parameters, Test feed, Plant extract