Morphological study of the ileal Peyer’s patches of mammals
| dc.contributor.author | Antallo,Hando Hussein | |
| dc.date.accessioned | 2025-10-02T11:38:41Z | |
| dc.date.available | 2025-10-02T11:38:41Z | |
| dc.date.issued | 2001 | |
| dc.description | Dissertation | |
| dc.description.abstract | Ileal Peyer’s patches of some mammals such as sheep and goats have similar morphological characteristics to the avian bursa of Fabricius. The objective of this study was therefore to obtain more data on the morphological properties and life history of ileal Peyer’s patches in a wider range of mammalian species. Thus, gross and histologic methods were used to evaluate the morphological changes in the ileal Peyer’s patches during fetal, youth and adult periods in wildebeests, reedbucks, cattle, donkeys, pigs, dogs, cats, wild rats, giant rats, baboons and vervet monkeys. In each age group three animals were used. Grossly, no Peyer’s patches were visible in duodenum, jejunum and ileum of fetuses except donkey fetuses, which had 29 ileal Peyer’s patches and 40 jejunal Peyer’s patches. However, microscopic evaluation of fetal ileal samples from fetuses of all mentioned species except rats at about mid gestation, showed accumulation of lymphoid cells in the sub-mucosa. During late fetal period, cattle and donkey fetuses had conical follicles while dogs had round follicles. In addition, bovine fetus ileal Peyer’s patch follicles showed distinct cortico-medulla differentiation. Young wildebeests, reedbucks, cattle, pigs, dogs and cats had long continuous band ofileal Peyer’s patch that covered the ileum and extended into the jejunum. Donkeys, baboons and vervet monkeys possessed 32, 1, 3 oval shaped individual ileal Peyer’s patches respectively, while rats had nopatches. Young wildebeests, reedbucks, cattle, cats, baboons and vervet monkeys possessed oval shaped jejunal Peyer’s patches numbering 32, 10, 26, 3, 12 and 18, respectively. Foals and puppies had round jejunal Peyer’s patches that numbered 48 and 8, respectively. No jejunal Peyer’s patches were seen in piglets and rats. Duodenal Peyer’s patches were only seen in puppies. Microscopically, ileal Peyer’s iii patch showed follicles that were sac-like, tightly packed, with clear cortico-medulla differentiation and small domes, corona and interfollicular areas. The adults of wildebeest, rcedbuck, cattle, pig, donkey, dog and cat had no grossly visible ileal Peyer’s patches. However, microscopically, sub-mucosa was filled with connective tissue. Nevertheless, wild rats had 2 and giant rats had 8 small round ileal Peyer’s patches that contained pear-shaped follicles, wider domes, conspicuous corona and large interfollicular areas. All animals under study possessed jejunal Peyer’s patches, which were bigger than those of respective youths and their numbers averaged 55 in wildebeest, 15 in rcedbuck, 37 in cattle, 8 in pig, 57 in donkey, 9 in dog, 6 in cat, 3 in wild rat and 17 in giant rat. Again, 3 duodenal Peyer’s patches were seen in dogs. Adults of non-human primates were not obtained. The study has therefore demonstrated presence of a continuous long ileal Peyer’s patches in young animals in orders; Artiodactyla and Carnivora while young animals of the order Perissodactyla had discrete round patches. At least, the study has also demonstrated a prenatal maturation of the ileal Peyer’s patches in the mammalian ordersArtiodactyla, Perissodactyla and Carnivora which is followed by full maturation at young age and lastly by involution at adulthood except in rats. This morphological pattern resembles that of avian bursa of Fabricius. | |
| dc.identifier.uri | https://www.suaire.sua.ac.tz/handle/123456789/7074 | |
| dc.language.iso | en | |
| dc.publisher | Sokoine University of Agriculture | |
| dc.subject | Morphological study | |
| dc.subject | Sheep and goats | |
| dc.subject | Avian bursa | |
| dc.subject | Fabricius | |
| dc.title | Morphological study of the ileal Peyer’s patches of mammals | |
| dc.type | Thesis |