Human, animal and plant health benefits of glucosinolates and strategies for enhanced Bioactivity: a systematic review
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Glucosinolates (GSs) are common anionic plant secondary metabolites in the order
Brassicales. Together with glucosinolate hydrolysis products (GSHPs), they have recently gained
much attention due to their biological activities and mechanisms of action. We review herein the
health benefits of GSs/GSHPs, approaches to improve the plant contents, their bioavailability and
bioactivity. In this review, only literature published between 2010 and March 2020 was retrieved
from various scientific databases. Findings indicate that these compounds (natural, pure, synthetic,
and derivatives) play an important role in human/animal health (disease therapy and prevention),
plant health (defense chemicals, biofumigants/biocides), and food industries (preservatives). Overall,
much interest is focused on in vitro studies as anti-cancer and antimicrobial agents. GS/GSHP levels
improvement in plants utilizes mostly biotic/abiotic stresses and short periods of phytohormone
application. Their availability and bioactivity are directly proportional to their contents at the source,
which is affected by methods of food preparation, processing, and extraction. This review concludes
that, to a greater extent, there is a need to explore and improve GS-rich sources, which should be
emphasized to obtain natural bioactive compounds/active ingredients that can be included among
synthetic and commercial products for use in maintaining and promoting health. Furthermore,
the development of advanced research on compounds pharmacokinetics, their molecular mode
of action, genetics based on biosynthesis, their uses in promoting the health of living organisms
is highlighted.
Description
Journal Article
Keywords
Glucosinolates, Glucosinolate hydrolysis products, Natural compounds, Secondary metabolites, Bioactivity, Improvement, Bioavailability