Dengue virus infection and associated risk factors in Africa: a systematic review and meta-analysis

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dc.contributor.authorMwanyika, Gaspary O.
dc.contributor.authorMboera, Leonard E. G.
dc.contributor.authorRugarabamu, Sima
dc.contributor.authorNgingo, Baraka
dc.contributor.authorSindato, Calvin
dc.contributor.authorLutwama, Julius J.
dc.contributor.authorPaweska, Janusz T.
dc.contributor.authorMisinzo, Gerald
dc.date.accessioned2022-09-06T09:40:14Z
dc.date.available2022-09-06T09:40:14Z
dc.date.issued2021
dc.descriptionJournal Articleen_US
dc.description.abstractDengue contributes a significant burden on global public health and economies. In Africa, the burden of dengue virus (DENV) infection is not well described. This review was undertaken to determine the prevalence of dengue and associated risk factors. A literature search was done on PubMed/MEDLINE, Scopus, Embase, and Google Scholar databases to identify articles published be- tween 1960 and 2020. Meta-analysis was performed using a random-effect model at a 95% confidence interval, followed by subgroup meta-analysis to determine the overall prevalence. Between 1960 and 2020, 45 outbreaks were identified, of which 17 and 16 occurred in East and West Africa, respectively. Dengue virus serotype 1 (DENV-1) and DENV-2 were the dominant serotypes contributing to 60% of the epidemics. Of 2211 cases reported between 2009 and 2020; 1954 (88.4%) were reported during outbreaks. Overall, the prevalence of dengue was 29% (95% CI: 20–39%) and 3% (95% CI: 1–5%) during the outbreak and non-outbreak periods, respectively. Old age (6/21 studies), lack of mosquito control (6/21), urban residence (4/21), climate change (3/21), and recent history of travel (3/21) were the leading risk factors. This review reports a high burden of dengue and increased risk of severe disease in Africa. Our findings provide useful information for clinical practice and health policy decisions to implement effective interventions.en_US
dc.identifier.urihttp://www.suaire.sua.ac.tz/handle/123456789/4521
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectDengue virusen_US
dc.subjectPrevalenceen_US
dc.subjectRisk factorsen_US
dc.subjectAfricaen_US
dc.titleDengue virus infection and associated risk factors in Africa: a systematic review and meta-analysisen_US
dc.typeArticleen_US
dc.urlhttps://doi.org/10.3390/v13040536en_US

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