Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?

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dc.contributor.authorBENNETT, KELLY
dc.contributor.authorSHIJA, FORTUNATE
dc.contributor.authorKADDUMUKASA, MARTHA
dc.contributor.authorMISINZO, GERALD
dc.contributor.authorDJOUAKA, ROUSSEAU
dc.contributor.authorHARRIS, ANGELA
dc.contributor.authorL U T W A M A, J U L I U S
dc.contributor.authorW A L T O N, C A T H E R I N E
dc.date.accessioned2021-11-22T06:10:22Z
dc.date.available2021-11-22T06:10:22Z
dc.date.issued2016-06-22
dc.description.abstractIncreasing globalization has promoted the spread of exotic species, including disease vectors. Understanding the evolutionary processes involved in such colonizations is both of intrinsic biological interest and important to predict and mitigate future dis- ease risks. The Aedes aegypti mosquito is a major vector of dengue, chikungunya and Zika, the worldwide spread of which has been facilitated by Ae. aegypti’s adaption to human-modified environments. Understanding the evolutionary processes involved in this invasion requires characterization of the genetic make-up of the source population (s). The application of approximate Bayesian computation (ABC) to sequence data from four nuclear and one mitochondrial marker revealed that African populations of Ae. aegypti best fit a demographic model of lineage diversification, historical admixture and recent population structuring. As ancestral Ae. aegypti were dependent on forests, this population history is consistent with the effects of forest fragmentation and expansion driven by Pleistocene climatic change. Alternatively, or additionally, histori- cal human movement across the continent may have facilitated their recent spread and mixing. ABC analysis and haplotype networks support earlier inferences of a single out-of-Africa colonization event, while a cline of decreasing genetic diversity indicates that Ae. aegypti moved first from Africa to the Americas and then to Asia. ABC analy- sis was unable to verify this colonization route, possibly because the genetic signal of admixture obscures the true colonization pathway. By increasing genetic diversity and forming novel allelic combinations, divergence and historical admixture within Africa could have provided the adaptive potential needed for the successful worldwide spread of Ae. aegypti.en_US
dc.identifier.issnPrint: 0962-1083
dc.identifier.issnElectronic: 1365-294X
dc.identifier.urihttps://www.suaire.sua.ac.tz/handle/123456789/3894
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltd.en_US
dc.subjectapproximate Bayesian computationen_US
dc.subjectdomestication,en_US
dc.subjectforest fragmentationen_US
dc.subjectinvasive speciesen_US
dc.subjectPleistocene climatic changeen_US
dc.titleHistorical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?en_US
dc.typeArticleen_US
dc.urlhttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-294Xen_US

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