Theses and Dissertations Collection

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Browsing Theses and Dissertations Collection by Subject "Nervous systems-animals"

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    The organisation of the enteric nervous system in the pig and goat, and changes induced by granulomatous inflammation in pigs infected with schistosoma japonicum
    (The Royal Veterinary and Agricultural University Copenhagen, Denmark, 2001) Begira, Onesmo Balemba
    This thesis is composed of four chapters, six papers and a summary in English as well as in Danish. In chapters one to three the literature in the fields of study has been reviewed and the objectives set forth in the current investigation and what was achieved are highlighted. Chapter four gives a brief overview discussion of the results and perspectives. The remaining part of the thesis is composed of publications/manuscripts describing findings from the current work as well as respective discussions and conclusions and will be referred to as papers I-VI in the text. Paper I deals with the organisation of the enteric nervous system in the small intestine of the pig with emphasis on the submucous and mucous plexuses. Paper II gives an insight of the organisation of the ganglia, isolated neurons and subplexuses in the mucous plexus in the intestine of the pig. Paper III presents the organisation of the enteric nervous system in the goat with emphasis on the subdivisions in the outer and inner submucous plexuses and salient features to differentiate them as well as the extent of ganglia and isolated neurones in the mucous plexus. Intra-plexus variations along segments, inter-plexus variation with respect to the size of ganglia nerve stands and neurons are elaborated. Paper IV focuses on problems associated with methods used to quantify neurons, enterochromaffin cells as well as estimation of the surface area of Peyer’s patches in the gut in the previous studies. A simple, cheap, unbiased sampling method is demonstrated using the pig jejunum as an example. Papers V and VI present findings on the plasticity of neurochemical contents in the enteric nervous tissue in the caecum and colon of pigs infected with Schistosoma japonicum. Paper I: O.B. Balemba, M.-L. Grpndahl, G.K. Mbassa, W.D. Semuguruka, A. Hay-Schmidt, E. Skadhauge, V. Dantzer. The organisation of the enteric nervous system in the submucous and mucous layers of the small intestine of the pig studied by VIP and neurofilament protein immunohistochemistry. Journal of Anatomy 1998; 192: 257-267. Paper II: O.B. Balemba, A. Hay-Schmidt, R.J. Assey, C.K.B. Kahwa, W.D. Semuguruka, V. Dantzer. An immunohistochemical study of the organisation of ganglia and nerve fibres in the mucosa of the porcine intestine. Autonomic Neuroscience: Basic and Clinical. (Submitted). Paper III: O.B. Balemba, W.D. Semuguruka, A. Hay-Schmidt, V. Dantzer. The organisation and variations of ganglionated plexuses of the enteric nervous system in the goat. Journal of Anatomy. (Submitted). Paper IV: O.B. Balemba, A. Hay-Schmidt, V. Dantzer, H.J.G. Gundersen. A very simple and efficient stereological sampling scheme for large mammalian gut, with estimation of the total number of specific neurons in distinct plexuses using unbiased principles. (Draft). Paper V: O. B. Balemba, W. D. Semuguruka, A. Hay-Schmidt, M. V. Johansen, V. Dantzer. Vasoactive intestinal peptide and substance P-like immunoreactivities in the enteric nervous system of the pig correlate with the severity of pathological changes induced by Schistosoma japonicum. International Journal for Parasitology. (In press). Paper VI: O.B. Balemba, K. Mortensen, W.D. Semuguruka, A. Hay-Schmidt, M.V. Johansen, V. Dantzer. Neuronal nitric oxide synthase activity is increased during granulomatous inflammation in the colon and caecum of pigs infected with Schistosoma japonicum. Autonomic Neuroscience: Basic and Clinical. (Submitted).